Science was born from Alchemy, the search for the prima-materia was derived from Atlantean knowledge.
Science is still trying to find the prima-materia through atom smashing.
The doorway to prima materia is the valance shell or valence electron, especially apparent in transition metals.
The on-off oscillation of matter is the door opening and closing to the prima-materia.
The base substance of matter is allied to the ground of consciousness and is not so much to be found 'inside' the particulate, but is accessed via the 'outside' of the atom.